Sugar acids and derivatives
Medchemexpress LLC Chmfl-pi4k-127 | 2377604-81-2 | 99.9% | 402.85 g/mol | C18H15ClN4O3S | 10 MG
CHMFL-PI4K-127 is a potent, selective Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K) inhibitor provided for research use. It exhibits sub-nanomolar enzymatic potency and cellular antimalarial activity, and is supplied at high chemical purity suitable for in vitro and in vivo studies.
- Potent PfPI4K inhibition (IC50 ~0.9 nM).
- Demonstrated cellular antimalarial activity (EC50 ~25.1 nM).
- High chemical purity for reliable experimental results (>99.9%).
- Available in research-scale quantities for assay development.
- Soluble in DMSO for standard compound handling and dosing.
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.39% | 783.29 | 25 MG
PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Connects ligands for Cereblon and BRD4
- Utilizes the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Interferon alpha/beta receptor 1 Antibody (YA3833) | 110-130 kDa | 10 UL
This Interferon alpha/beta receptor 1 Antibody (YA3833) is a mouse-derived, non-conjugated IgG1 monoclonal antibody targeting Interferon alpha/beta receptor 1. It forms a heterodimeric receptor with IFNAR2 for type I interferons, activating the JAK-STAT signaling cascade to regulate interferon-responsive genes.
- Mouse-derived monoclonal antibody
- Non-conjugated IgG1 isotype
- Targets interferon alpha/beta receptor 1
- Reacts with human and mouse species
- Suitable for WB, IHC-P, FC, and ELISA applications
- Supplied as a liquid in PBS with 0.05% sodium azide
- Purity is affinity purified
- Store at -20°C for one year; avoid repeated freeze/thaw cycles
Medchemexpress LLC Integrin alpha V bet 20ug | 20ug
Integrin alpha V beta 3 (ITGAV ITGB3) functions as a receptor for CD40LG enhancing Lilrb4a inhibitory effects on mast cell activation It suppresses marginal zone B cell antibody production through Lilrb4a interaction ITGAV ITGB3 forming a heterodimer with ITGAV interacts with ligands such as RAB25 CIB1 FBLN5 and more It also forms a complex with PTPRZ1 and PTN stimulating endothelial cell migration Integrin alpha V beta 6 Protein Mouse (HEK293 His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 6 Protein Mouse (HEK293 His) has molecular weight of 90-140 kDa
Medchemexpress LLC Beta-D-glucuronide-pNP-carbonate | 894095-98-8 | MFCD31715405 | >96.0% | 913.83 g/mol | C45H43N3O18 | 50 MG
β-D-glucuronide-pNP-carbonate is a glycosidase-cleavable antibody-drug conjugate (ADC) linker that contains a para-nitrophenyl carbonate reactive handle and a β-D-glucuronide cleavable trigger. It is supplied as a solid for research use and is designed to release payloads upon enzymatic cleavage by glucuronidase.
- Glycosidase-cleavable linker for targeted payload release.
- Para-nitrophenyl carbonate reactive handle for payload attachment.
- Solid form suitable for standard laboratory handling.
- Available in small research-scale quantities for synthesis work.
- Intended for research use only; not for clinical or human use.
Medchemexpress LLC Aloeresin D | 105317-67-7 | MFCD32004290 | 99.5% | 556.56 | C29H32O11 | 10 MG
Aloeresin D is a chromone glycoside isolated from Aloe vera that inhibits β-secretase (BACE1) with a reported IC50 of 39 μM. It is supplied as a purified research compound with defined solubility and storage recommendations for biochemical and pharmacological studies.
- Chromone glycoside isolated from Aloe vera.
- Inhibits β-secretase (BACE1); IC50 = 39 μM.
- High purity (≈99.5%).
- Molecular formula C29H32O11; molecular weight 556.56 g/mol.
- Soluble in DMSO (250 mg/mL); reported in vivo solubility ≥2.08 mg/mL.
- Solid storage: 4°C, sealed, protected from moisture and light.
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | C106H162FN9O37 | 10 MG
OBI-992 drug-linker is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis. It links the TOP1 inhibitor exatecan to a cleavable linker to enable targeted delivery of the payload; preclinical studies report antitumor activity in mouse and PDX models. Supplied as a solid for research use, the product includes specified purity and storage recommendations for laboratory handling.
- Composed of exatecan linked to a cleavable linker.
- Demonstrated antitumor activity in preclinical models.
- High molecular weight compound suitable for ADC synthesis.
- Provided as a white to yellow solid.
- Purity 96.6%.
- Molecular weight 2173.46.
- Storage: sealed, away from moisture and light; in solvent -80°C for 6 months, -20°C for 1 month.
- Supplied in a 10 mg package for research use.
Medchemexpress LLC D-praziquanamine ((-)-praziquanamine) | 55375-92-3 | MFCD30491837 | 98.9% | 202.26 g/mol | C12H14N2O | 10 MG
D-Praziquanamine ((-)-praziquanamine) is the stereoisomer of L-praziquanamine, provided as a research reagent for use as an experimental control in biochemical and pharmacological studies.
- Isomer of L-praziquanamine, intended for use as an experimental control.
- CAS number 55375-92-3.
- Molecular formula C12H14N2O, molecular weight 202.26 g/mol.
- Typical purity ~98.9% (batch-specific; see certificate of analysis for details).
- Appearance: solid; also offered as a 10 mM solution in DMSO.
- Available in small sample sizes and milligram-scale quantities (for example, 10 mg).
Medchemexpress LLC Protac BET-binding moiety 2 | 916493-82-8 | 99.8% | 10 MG
Small-molecule BET bromodomain inhibitor intended as the BET-binding ligand component in PROTAC constructs and for biochemical and cell-based research applications. Supplied as a solid or as a 10 mM solution in DMSO, with reported high purity and identifying registry information for compound verification.
- Functions as a BET bromodomain ligand for PROTAC design and target engagement studies.
- Available as solid powder and as a 10 mM solution in DMSO for assay flexibility.
- High reported purity suitable for research use.
- Characterized by CAS 916493-82-8 and molecular weight 444.89 for identification.
- Provided for research use only; not for human or clinical use.
Medchemexpress LLC Prosaikogenin D | 103629-72-7 | 10 MG
Prosaikogenin D is isolated from the roots of Buleurum bicaule Helm (Apiaceae) and exhibits anti-cancer activity.
- Suppresses the proliferation of A549 cells with an IC50 of 57.2 μg/mL.
Medchemexpress LLC Azido-PEG4-beta-D-glucose | 1609083-15-9 | 99.9% | 381.38 | 25 MG
Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This click chemistry reagent contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide functional group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Intended for research use only
Medchemexpress LLC D-Glucuronic acid sodium monohydrate-13C6 | 207300-70-7 | 1 MG
D-Glucuronic acid sodium monohydrate-13C6 is a 13C-labeled endogenous metabolite. This compound serves as a tracer and an internal standard for various quantitative analyses.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC N-acetylneuraminic acid-13C-3 | 131-48-6 | MFCD00006620 | 99.0% | 310.26 | C10H19NO9 (13C labeled) | 10 MG
N-Acetylneuraminic acid-13C-3 is a stable isotope-labeled form of N-acetylneuraminic acid used as an internal standard, tracer, or reference material in analytical chemistry and metabolomics for accurate quantification and metabolic tracing.
- 13C isotopic labeling at the 3-position for tracer studies.
- High purity, 99.0%.
- Suitable as an internal standard for LC-MS/MS quantification.
- Available in small mass quantities for analytical applications.
- Recommended storage: powder at -20°C for long-term, 4°C for short-term.